Viral respiratory tract infection and exacerbations of asthma in adult patients.

Viral respiratory tract infection and exacerbations of asthma in adult patients.

The role of viral respiratory tract infections in acute exacerbations of asthma was studied prospectively in 31 patients with atopic asthma aged 15-56 years. Patients recorded symptom scores for asthma and peak expiratory flow rate daily for 11 months. In addition, they reported for detailed clinical, functional, and virological study every four weeks and as soon as possible after the onset of ...

The Role of Leukotrienes in Respiratory Tract and Asthma

Polyunsaturated fatty acids play a role as precursors of biolo­gically active compounds that can act as mediators or modulators  of various cell functions. Thus three main groups of derivatives­ the prostaglandins, the thromboxanes, and recently discovered  leukotrienes are formed by oxygenation and further transformation of various polyunsaturated fatty acids of which arachidonic acid  plays t...

Asthma exacerbation and viral infection in adult patients, Brazil.

Respiratory viral infection, epithelial cytokines, and innate lymphoid cells in asthma exacerbations.

Exacerbations of asthma are most commonly triggered by viral infections, which amplify allergic inflammation. Cytokines released by virus-infected AECs may be important in driving this response. This review focuses on accumulating evidence in support of a role for epithelial cytokines, including IL-33, IL-25, and TSLP, as well as their targets, type 2 innate lymphoid cells (ILC2s), in the patho...

Prevalence of respiratory viral infection in children hospitalized for acute lower respiratory tract diseases, and association of rhinovirus and influenza virus with asthma exacerbations

PURPOSE In this study, we aimed to investigate the prevalence of year-round respiratory viral infection in children with lower respiratory tract infection (LRTI) and the relationship between respiratory viral infection and allergen sensitization in exacerbating asthma. METHODS We investigated the sources for acute LRTIs in children admitted to our hospital from May 2010 to April 2011. The 6 m...